1/1/2024 0 Comments Isfv physiologyNo severe adverse events occurred during the procedure and follow-up. A significant difference of the fat retention was also observed between the SVF-assisted and conventional group (P = .0346). Volume retention was measured by magnetic resonance imaging, and clinical photographs were taken for outcome evaluation. The ADSCs-assisted group received the mixture of ADSCs-enriched fat graft supplemented with 5 × 10 5 ADSCs/mL fat. The SVF-assisted group received SVF-assisted AFG at the SVF:fat ratio of 1:1. Participants were randomly assigned into three AFG groups: conventional group, SVF-assisted group, and ADSCs-assisted group. A pilot study with a 6-month follow-up among 18 LoS patients was conducted. We aimed to compare the feasibility and efficacy of improving fat retention in LoS patients among the ADSCs-assisted, the stromal vascular fraction (SVF)-assisted and conventional AFG methods. Adipose-derived stem cells (ADSCs) have shown potential effects in improving fat retention. Autologous fat grafting (AFG) is used for volume restoration but with low-fat retention due to various reasons. In patients with localized scleroderma (LoS), facial deformity induced by subcutaneous atrophy greatly reduces life quality.
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